Macrophage Activation Syndrome in Children with Systemic Juvenile Idiopathic Arthritis Successfully Treated with Megadose Methyl Prednisolone Therapy
نویسندگان
چکیده
منابع مشابه
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis treated with tocilizumab
Introduction Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of systemic juvenile idiopathic arthritis (sJIA). Changes in therapies, including biologics, have been associated with the onset of MAS. Interleukin-6 (IL-6) plays a major pathogenic role in sJIA; data in animals suggest that high IL-6 levels contribute to the triggering of MAS [1]. Treatment with the ...
متن کاملMacrophage activation syndrome during treatment with biological therapy in patients with systemic juvenile idiopathic arthritis
Introduction Macrophage activation syndrome (MAS) is a severe complication of autoimmune diseases. It is more often associated with Systemic Juvenile Idiopathic Arthritis (sJIA). It is difficult to distinguish the MAS from a flare of sJIA, infection or medicinal side effects. The MAS can occur during a flare, an infection, a change in the medication or as a side effect of the treatment administ...
متن کاملMacrophage activation syndrome in an inadequately treated patient with systemic onset juvenile idiopathic arthritis.
Macrophage activation syndrome is a rare and potentially life threatening complication of childhood rheumatic disorders. It is described most commonly with systemic onset juvenile idiopathic arthritis (soJIA). The major clinical manifestations are non-remitting fever, hepatosplenomegaly, lymphadenopathy, bleeding diathesis, altered mental status and rash and may mimic a fl are of soJIA. The cha...
متن کاملMacrophage activation syndrome in 13 children with systemic-onset juvenile idiopathic arthritis.
BACKGROUND Macrophage activation syndrome (MAS) is a severe, potentially life-threatening condition induced by chronic rheumatic diseases, especially systemic-onset juvenile idiopathic arthritis (SoJIA) in childhood. This study aimed to analyze the clinical and laboratory characteristics of systemic-onset juvenile idiopathic arthritis (SoJIA) with macrophage activation syndrome (MAS) in 13 pati...
متن کاملMacrophage activation syndrome in children with systemic juvenile idiopathic arthritis: a retrospective study on 7 patients
Results Seven children (4 females, 3 males) were studied. Two children had incomplete MAS. The underlying disease was not identified in one child. MAS developed during the course of underlying disease (sJIA) in three children. Clinical manifestations at diagnosis included high persistent fever (7), skin rash (6), hepatosplenomegaly (7), lymphadenopathy (6), hemorrhages (5) and central nervous s...
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ژورنال
عنوان ژورنال: The Journal of Pediatric Research
سال: 2015
ISSN: 2147-9445
DOI: 10.4274/jpr.30602